Reverse engineering a protein: the mechanochemistry of ATP synthase
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منابع مشابه
Reverse engineering a protein: the mechanochemistry of ATP synthase.
ATP synthase comprises two rotary motors in one. The F(1) motor can generate a mechanical torque using the hydrolysis energy of ATP. The F(o) motor generates a rotary torque in the opposite direction, but it employs a transmembrane proton motive force. Each motor can be reversed: The F(o) motor can drive the F(1) motor in reverse to synthesize ATP, and the F(1) motor can drive the F(o) motor in...
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All living species use ATP as a general source of energy by hydrolysing it into ADP and phosphate. In most species the regeneration of this vital molecule is catalysed by the H+-transporting F1F0 ATP synthases, marvellous machines that couple the flow of protons down an electrochemical gradient to form ATP from ADP and phosphate. Under certain circumstances these enzymes can also work in the re...
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An X-ray structure of the F1 portion of the mitochondrial ATP synthase shows asymmetry and differences in nucleotide binding of the catalytic beta subunits that support the binding change mechanism with an internal rotation of the gamma subunit. Other structural and mutational probes of the F1 and F0 portions of the ATP synthase are reviewed, together with kinetic and other evaluations of catal...
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Mutations in human mitochondrial DNA are a well recognized cause of disease. A mutation at nucleotide position 8993 of human mitochondrial DNA, located within the gene for ATP synthase subunit 6, is associated with the neurological muscle weakness, ataxia, and retinitis pigmentosa (NARP) syndrome. To enable analysis of this mutation in control nuclear backgrounds, two different cell lines were ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2000
ISSN: 0005-2728
DOI: 10.1016/s0005-2728(00)00096-7